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Before (left) and after (right) results after four days of. 9 Weiss JS, Ellis CN, et al: “Topical tretinoin improves photo aged skin: A double- blind vehicle.Biopsy specimens were obtained from the facial skin of 20 patients before and after treatment. Topical tretinoin therapy was found to induce a significant.No statistically significant difference was found between patients treated with TCA and tretinoin (before and after peel) and those with TCA alone.